TSM may refer to:

• Taiwan Semiconductor Manufacturing Company, a semiconductor foundry
• IBM Tivoli Storage Manager, a backup software product
• Texas Student Media, a student media operation of The University of Texas at Austin
• Toulouse School of Management, a French management college
• Trinity School for Ministry, a seminary in Pennsylvania
• Trapezoidal Shadow Map, a technique for real-time shadow mapping
• Team SoloMid, a professional esports organization
• Team service management, a management framework
• Trusted service manager, a business role in the mobile payment environment
• Teaching-suggestion-motivation, a test of inventive step and non-obviousness in patent law
• Superior Military Court (Portuguese: Tribunal Superior Militar), one of the federal courts of Brazil
• Station code for Tasikmalaya railway station