glucose 6 phosphate dehydrogenase disease - ترجمة إلى إنجليزي
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glucose 6 phosphate dehydrogenase disease - ترجمة إلى إنجليزي

G6PD; Glucose-6-phosphate-dehydrogenase; Glucose-6-Phosphate Dehydrogenase; Glucose 6-p dehydrogenase; Glucose 6-phosphate dehydrogenase; G6PD1; G6pd1; G6PDH; G6P dehydrogenase; G^PD; G6PD (gene); EC; D-glucose-6-phosphate:NADP+ 1-oxidoreductase
  • Substrate binding site of G6PD bound to G6P (shown in cream), from [ 2BHL]. Phosphorus is shown in orange. Oxygen atoms of crystallographic waters are shown as red spheres. The conserved 9-peptide sequence of G6PD, and the partially conserved 5-residue sequence of G6PD are shown in cyan and magenta respectively. All other amino acids from G6PD are shown in black. Hydrogen bonding and electrostatic interactions are shown by green dashed lines. All green dashes represent distances of less than 3.7 Å.

glucose 6 phosphate dehydrogenase disease      
‎ داءُ نازِعَةِ هيدْرُوجينِ الغلُوكُوزِ-6- فُسْفات‎
glucose-6-phosphate dehydrogenase         
نازِعَةُ هيدروجينِ الغلوكوز -6- فسفات
glucose 6 phosphatase         
  • Breakdown of the various constituents of glucose 6-phosphatase system deficiency
Glucose-6-phosphatase; Glucose 6 phosphatase; EC; D-glucose-6-phosphate phosphohydrolase
‎ غلُوكُوز -6- فُسْفاتاز‎


Peripheral Data Storage Processor


Glucose-6-phosphate dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) (EC is a cytosolic enzyme that catalyzes the chemical reaction

D-glucose 6-phosphate + NADP+ + H2O ⇌ 6-phospho-D-glucono-1,5-lactone + NADPH + H+

This enzyme participates in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage from compounds like hydrogen peroxide. Of greater quantitative importance is the production of NADPH for tissues involved in biosynthesis of fatty acids or isoprenoids, such as the liver, mammary glands, adipose tissue, and the adrenal glands. G6PD reduces NADP+ to NADPH while oxidizing glucose-6-phosphate. Glucose-6-phosphate dehydrogenase is also an enzyme in the Entner–Doudoroff pathway, a type of glycolysis.

Clinically, an X-linked genetic deficiency of G6PD makes a human prone to non-immune hemolytic anemia.