Avignon (, also US: ; French: [aviɲɔ̃] (listen); Provençal: Avinhon (Classical norm) or Avignoun (Mistralian norm), IPA: [aviˈɲun]; Latin: Avenio) is the prefecture of the Vaucluse department in the Provence-Alpes-Côte d'Azur region of Southeastern France. Located on the left bank of the river Rhône, the commune had a population of 93,671 as of the census results of 2017, with about 16,000 (estimate from Avignon's municipal services) living in the ancient town centre enclosed by its medieval walls. It is France's 35th largest metropolitan area according to INSEE with 337,039 inhabitants (2020), and France's 13th largest urban unit with 459,533 inhabitants (2020). Its urban area was the fastest-growing in France from 1999 until 2010 with an increase of 76% of its population and an area increase of 136%. The Communauté d'agglomération du Grand Avignon, a cooperation structure of 16 communes, had 197,102 inhabitants in 2022.

Between 1309 and 1377, during the Avignon Papacy, seven successive popes resided in Avignon and in 1348 Pope Clement VI bought the town from Joanna I of Naples. Papal control persisted until 1791 when during the French Revolution it became part of France. The city is now the capital of the Vaucluse department and one of the few French cities to have preserved its city walls.

The historic centre, which includes the Palais des Papes, the cathedral and the Pont d'Avignon, became a UNESCO World Heritage Site in 1995 because of its architecture and importance during the 14th and 15th centuries. The medieval monuments and the annual Festival d'Avignon (commonly called: "Festival In d'Avignon") and its accompanying Festival Off d'Avignon - one of the world's largest festivals for performing arts, have helped to make the town a major centre for tourism.