NIE or Nie may refer to:

• Nie (surname), Chinese surname
• NIE (magazine), a Polish weekly magazine
• NIE (resistance) (short for Niepodległość), the Polish anti-communist resistance movement in 1940s
• NIE number, the national tax identification number for foreigners in Spain

It is an acronym for:

• Napoleon in Europe, historical board game
• National Institute of Education, school in Singapore that provides professional training for teachers
• National Institute of Electronics (Pakistan), Pakistani research institution
• National Institute of Engineering, a college in Karnataka, India, now NIE University
• National Intelligence Estimate, a type of report by the United States Intelligence Community
• Network Integration Evaluation
• New institutional economics
• Newly industrializing economy
• Newspapers in Education, a program encouraging the use of newspapers in the classroom as a teaching tool of essential academic and life skills
• Newton's Institute of Engineering, Macherla, school in Andhra Pradesh, India
• Northern Ireland Electricity
• Northern Ireland Executive, devolved administration in Northern Ireland