Synodical College was a four-year college in Fulton, Missouri, providing education for young women from 1873 until 1928. The school operated under the auspices of the Presbyterian Church. The Synod, meeting in 1871 at Cape Girardeau, Missouri, accepted an offer that year of $16,500 in cash subscriptions from the citizens of Callaway County and 4 acres (16,000 m²) of land, donated by Daniel M. Tucker. The college opened in 1873.

Synodical, also known as Fulton Female Synodical College, was a successor institution to the Fulton Female Academy, which had been opened by Rev. William W. Robertson in 1842 as one of the earliest American women's colleges. It became affiliated with the Presbyterian Church in 1871.