BRB may refer to:

• Bank of the Republic of Burundi or Banque de la République du Burundi, the official name in French of the central bank of Burundi
• Barbados, ISO country code BRB, country in the Caribbean Sea
• Barreirinhas Airport, IATA Code BRB, airport in Barreirinhas, Brazil
• "Be right back", in Internet/chat slang, also sometimes treated as a synonym of "bathroom break"
• The Beatles: Rock Band, 2009 music video game
• Benefits Review Board, a part of the United States Department of Labor
• Beta Ray Bill, a fictional character from the Marvel universe
• Beveled rim bowl, clay bowls most common in the 4th millennium B.C.
• Bibliothèque royale de Belgique, the Royal Library of Belgium
• Big red button, a type of command button
• Birmingham Royal Ballet, a ballet company
• Blaire Reinhard Band, a New Jersey rock band
• Blood-retinal barrier, cells in the eye that prevent certain substances from entering the tissue of the retina
• Brandenburg an der Havel, German car number plates BRB, town in Brandenburg, Germany
• BRB Internacional, a Spanish animation studio.
• Brienz Rothorn Bahn, a Swiss railway
• Brigade de répression du banditisme, a special police unit of the French Ministry of the Interior.
• Brazos River Bottom, an LGBT club in Houston
• British Railways Board, the former governing body of British Railways
  • BRB (Residuary) Limited, its successor
• Britton-Robinson buffer
• Buckling restrained brace, a specialized earthquake bracing system
• "BRB", a song by Bazzi from the album Cosmic