The Burroughs Large Systems Group produced a family of large 48-bit mainframes using stack machine instruction sets with dense syllables. The first machine in the family was the B5000 in 1961. It was optimized for compiling ALGOL 60 programs extremely well, using single-pass compilers. It evolved into the B5500. Subsequent major redesigns include the B6500/B6700 line and its successors, as well as the separate B8500 line.

In the 1970s, the Burroughs Corporation was organized into three divisions with very different product line architectures for high-end, mid-range, and entry-level business computer systems. Each division's product line grew from a different concept for how to optimize a computer's instruction set for particular programming languages. "Burroughs Large Systems" referred to all of these large-system product lines together, in contrast to the COBOL-optimized Medium Systems (B2000, B3000, and B4000) or the flexible-architecture Small Systems (B1000).