HDM may refer to:

• Haagsche Delftsche Mixed, a Dutch field hockey club based in Den Haag
• Haddenham & Thame Parkway railway station, in England
• Hamadan Airport in Iran
• Harvard Dictionary of Music
• Haus des Meeres, an aquarium in Vienna, Austria
• H. D. Moore, American computer security researcher
• HDM Furniture Industries, including furniture companies Henredon, Drexel Heritage and Maitland-Smith
• Herzog & de Meuron (HdM), a Swiss architectural firm
• High Standard HDM, a semiautomatic pistol
• His Dark Materials, a trilogy of novels by Philip Pullman
• Hockey Day Minnesota
• Holistic Data Management
• Hot dark matter, a form of dark matter
• House dust mite
• Hoy de monterrey (Cuban cigar brand)
• Hard Dynamic Monsters (CS:GO Team)
• Health Data Movers (a company providing healthcare IT services)