Ipe or IPE can refer to:

• Isopropyl ether, a chemical solvent, usually in the form of DIPE (diisopropyl ether)
• Icosapent ethyl, that is, ethyl eicosapentaenoic acid, an omega-3 lipid formulation
• L’Institut pour I’Expertise (IPE), that is, IPE Management School Paris, a private higher education institution in Paris, France
• International political economy, an academic discipline
• Ipê, trees in the genus Handroanthus and their wood
• Ipe (software), an extensible drawing editor
• Innotech Performance Exhaust (iPE), a manufacturer of exhaust system and wheels in Taiwan.
• Institute of Public Enterprise in India
• Integrity Policy Enforcement, a Linux Security Module (LSM) that enables additional security features
• International Petroleum Exchange (old name), that is, Intercontinental Exchange Futures (ICE Futures), a futures and options exchange
• International Petroleum Exposition, a former trade fair held periodically in Oklahoma from 1923 to 1979
• Interprofessional education, integration of specialties in professional education
• Immersion pulmonary edema, that is, swimming-induced pulmonary edema
• Interstitial pulmonary emphysema, that is, pulmonary interstitial emphysema, a rare lung condition in newborns
• Individual protective equipment, as personal protective equipment is sometimes called (especially in military NBC/ABC/WMD contexts)
• IPE, a European type of I-beam
• Île-du-Prince-Édouard, that is, Prince Edward Island, a province of Canada
• Ideal polarized electrode, a type of ideal electrode
• Icosahedral prism, a type of polytope in geometry
• iris pigment epithelium, a one-cell-thick layer of cuboidal cells lying behind the iris of the eye
• Pyrenean Ecology Institute, a research center from Spain