MAPK phosphatase - Definition. Was ist MAPK phosphatase
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Was (wer) ist MAPK phosphatase - definition


MAPK phosphatase         
  • The figure shows the interaction and cooperation of MEK, DUSP5 and DUSP6/MKP-3 within the cytoplasmic region and the nucleus. RAF activates MEK. Activated MEK phoshorylates ERK which can now be transported across the cell membrane by a transporter. Dephosphorylated ERK cannot leave the nucleus.
  • When activated MAPK binds to MKB this causes a conformational change of the DUSP region which activates MKP and activated MKP dephosphorylates MAPK thereby inactivating it.
CLASS OF ENZYMES
MAP kinase phosphatase; Mitogen-activated protein kinase phosphatase
MAPK phosphatases (MKPs) are the largest class of phosphatases involved in down-regulating Mitogen-activated protein kinases (MAPK) signaling. MAPK signalling pathways regulate multiple features of development and homeostasis.
Protein tyrosine phosphatase         
CLASS OF ENZYMES
Protein Tyrosine Phosphatase; Protein-tyrosine-phosphatase; Tyrosine phosphatase; Protein tyrosine phosphatases; Protein tyrosine phosphatase sigma; Non-receptor protein tyrosine phosphatase; EC 3.1.3.48; Protein-tyrosine-phosphate phosphohydrolase; Protein tyrosine phosphatase nonreceptor type 22
Protein tyrosine phosphatases are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Protein tyrosine (pTyr) phosphorylation is a common post-translational modification that can create novel recognition motifs for protein interactions and cellular localization, affect protein stability, and regulate enzyme activity.
Protein phosphatase         
CLASS OF ENZYMES
Protein phosphatases; Phosphoprotein phosphatase
A protein phosphatase is a phosphatase enzyme that removes a phosphate group from the phosphorylated amino acid residue of its substrate protein. Protein phosphorylation is one of the most common forms of reversible protein posttranslational modification (PTM), with up to 30% of all proteins being phosphorylated at any given time.