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Was (wer) ist hypertonicity$36833$ - definition
![A [[red blood cell]] in a hypertonic solution, causing water to move out of the cell.](https://commons.wikimedia.org/wiki/Special:FilePath/Blausen 0683 OsmoticFlow Hypertonic.png?width=200 "A [[red blood cell]] in a hypertonic solution, causing water to move out of the cell.")
![A [[red blood cell]] in a hypotonic solution, causing water to move into the cell.](https://commons.wikimedia.org/wiki/Special:FilePath/Blausen 0684 OsmoticFlow Hypotonic.png?width=200 "A [[red blood cell]] in a hypotonic solution, causing water to move into the cell.")
![Depiction of a [[red blood cell]] in an isotonic solution.](https://commons.wikimedia.org/wiki/Special:FilePath/Blausen 0685 OsmoticFlow Isotonic.png?width=200 "Depiction of a [[red blood cell]] in an isotonic solution.")
Wikipedia
Spasticity (from Greek spasmos- 'drawing, pulling') is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity, and hypertonia. It is also colloquially referred to as an unusual "tightness", stiffness, or "pull" of muscles.
Clinically, spasticity results from the loss of inhibition of motor neurons, causing excessive velocity-dependent muscle contraction. This ultimately leads to hyperreflexia, an exaggerated deep tendon reflex. Spasticity is often treated with the drug baclofen, which acts as an agonist at GABA receptors, which are inhibitory.
Spastic cerebral palsy is the most common form of cerebral palsy, which is a group of permanent movement problems that do not get worse over time. GABA's inhibitory actions contribute to baclofen's efficacy as an anti-spasticity agent.
