Prey is a first-person shooter video game developed by Human Head Studios, under contract for 3D Realms, and published by 2K Games, while the Xbox 360 version was ported by Venom Games. The game was initially released in North America and Europe on July 11, 2006. Prey uses a heavily modified version of id Tech 4 to use portals and variable gravity to create the environments the player explores.

The game's story is focused on Cherokee Domasi "Tommy" Tawodi as he, his girlfriend, and grandfather are abducted aboard an alien spaceship known as The Sphere as it consumes material, both inanimate and living, from Earth in order to sustain itself. Tommy's Cherokee heritage allows him to let his spirit roam freely at times and come back to life after dying, which gives Tommy an edge in his battle against the Sphere.

Prey had been in development in one form or another since 1995, and has had several major revisions. While the general approach to gameplay, including the use of portals, remained in the game, the story and setting changed several times. The game received generally positive reviews, with critics praising its graphics and gameplay but criticizing its multiplayer component for a lack of content.

Prey was a commercial success, selling more than one million copies in the first two months of its release and leading to the abortive development of its sequel Prey 2. The rights to Prey passed on to Bethesda Softworks, who released an unrelated game of the same name, developed by Arkane Studios, in 2017.