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purine-; 5"; -nucleotidase - Übersetzung nach Englisch
![The fives of all four suits in [[playing card]]s](https://commons.wikimedia.org/wiki/Special:FilePath/5 playing cards.jpg?width=200 "The fives of all four suits in [[playing card]]s")
![Illustration by [[Leonardo da Vinci]] of a [[regular dodecahedron]], from [[Luca Pacioli]]'s ''[[Divina proportione]]''](https://commons.wikimedia.org/wiki/Special:FilePath/De divina proportione - Illustration 13, crop.jpg?width=200 "Illustration by [[Leonardo da Vinci]] of a [[regular dodecahedron]], from [[Luca Pacioli]]'s ''[[Divina proportione]]''")
![tactility]]](https://commons.wikimedia.org/wiki/Special:FilePath/Five Senses.jpg?width=200 "tactility]]")
![International maritime signal flag for 5]]](https://commons.wikimedia.org/wiki/Special:FilePath/ICS Pennant Five.svg?width=200 "International maritime signal flag for 5]]")
![The first [[Pythagorean triple]], with a [[hypotenuse]] of <math>5</math>](https://commons.wikimedia.org/wiki/Special:FilePath/Pythagoras' Special Triples.svg?width=200 "The first [[Pythagorean triple]], with a [[hypotenuse]] of <math>5</math>")
![The main purine-derived [[nucleobase]]s.](https://commons.wikimedia.org/wiki/Special:FilePath/Blausen 0323 DNA Purines.png?width=200 "The main purine-derived [[nucleobase]]s.")
Definition
Wikipedia
5′-Nucleotidase (EC 3.1.3.5) is an enzyme which catalyzes the phosphorylytic cleavage of 5′-nucleotides. Although originally found in snake venom, the activity of 5'nucleotidase has been described for bacteria and plant cells, and is widely distributed in vertebrate tissue. In mammalian cells the enzyme is predominantly located in the plasma membrane and its primary role is in the conversion of extracellular nucleotides (e.g. 5'-AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. Consequently, the enzyme plays a key role in the metabolism of nucleotides.
The enzyme has a wide substrate specificity for nucleotides and has been shown to hydrolyze 5'nucleotides rapidly, ribose-5-phosphate slowly, and other phosphate esters extremely slowly (if at all).
The enzyme catalyses the following reaction:
- a 5′-nucleotide + H2O ⇌ a nucleoside + phosphate
The 5′-nucleotidase-catalyzed reaction of an AMP nucleotide to adenosine nucleoside is shown below:
