Methylenetetrahydrofolate reductase
MAMMALIAN PROTEIN FOUND IN HOMO SAPIENS
MTHFR; Methylenetetrahydrofolate reductase (NAD(P)H); Methylenetetrahydrofolate reductase (nadph2); MTHFR (gene); EC 1.7.99.5; EC 1.5.1.20; 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase; MTFHR
Methylenetetrahydrofolatereductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene. Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine.