P-type ATPase
GROUP OF MEMBRANE PROTEINS THAT CATALYZE CATION UPTAKE AND/OR EFFLUX DRIVEN BY ATP HYDROLYSIS
P-ATPase; P-type primary ion transport ATPase; E1-E2 ATPase; P-type pump
The P-type ATPases, also known as E1-E2 ATPases, are a large group of evolutionarily related ion and lipid pumps that are found in bacteria, archaea, and eukaryotes. P-type ATPases are α-helical bundle primary transporters named based upon their ability to catalyze auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue within the pump and their energy source, adenosine triphosphate (ATP).