X-linked lymphoproliferative disease
LYMPHOPROLIFERATIVE DISORDER
Duncan's disease; X-linked lymphoproliferative syndrome; Purtilo syndrome; XLP (hematology)
X-linked lymphoproliferative disease (also known as Duncan disease or Purtilo syndrome and abbreviated as XLP) is a lymphoproliferative disorder, usually caused by SH2DIA gene mutations in males. XLP-positive individuals experience immune system deficiencies that render them unable to effectively respond to the Epstein-Barr virus (EBV), a common virus in humans that typically induces mild symptoms or infectious mononucleosis (IM) in patients.