In physics and mathematics, a brachistochrone curve (from Ancient Greek βράχιστος χρόνος (brákhistos khrónos) 'shortest time'), or curve of fastest descent, is the one lying on the plane between a point A and a lower point B, where B is not directly below A, on which a bead slides frictionlessly under the influence of a uniform gravitational field to a given end point in the shortest time. The problem was posed by Johann Bernoulli in 1696.

The brachistochrone curve is the same shape as the tautochrone curve; both are cycloids. However, the portion of the cycloid used for each of the two varies. More specifically, the brachistochrone can use up to a complete rotation of the cycloid (at the limit when A and B are at the same level), but always starts at a cusp. In contrast, the tautochrone problem can use only up to the first half rotation, and always ends at the horizontal. The problem can be solved using tools from the calculus of variations and optimal control.

The curve is independent of both the mass of the test body and the local strength of gravity. Only a parameter is chosen so that the curve fits the starting point A and the ending point B. If the body is given an initial velocity at A, or if friction is taken into account, then the curve that minimizes time differs from the tautochrone curve.