Saints Row 2 is a 2008 action-adventure game developed by Volition and published by THQ. It is the sequel to 2006's Saints Row and the second installment in the Saints Row series. The game was released in October 2008 for the PlayStation 3 and Xbox 360, January 2009 for Microsoft Windows, and April 2016 for Linux. A mobile tie-in game was developed by G5 Entertainment and also released in October 2008. Saints Row 2 directly follows from the events of the first game, as the player's custom character awakens from a coma after five years to find that their gang, the 3rd Street Saints, has been disbanded, and their former territories taken over by newly-formed criminal syndicates and a corrupt corporation. With the help of new and old allies, the player attempts to rebuild the Saints and take back Stilwater from their rivals.

Story missions are unlocked by trading in "Respect" points, currency earned by completing minigames and side-missions. Outside of the main story, players can freely roam Stilwater, which has been expanded with new locations and consists of two main islands. The game is played from a third-person perspective and its world is navigated on-foot or by vehicle. Players can fight enemies using a variety of firearms, and call in non-playable gang members to assist them. An online multiplayer mode allows two players to explore Stilwater together while completing missions and activities, or multiple players to engage in a variety of cooperative and competitive game modes.

Saints Row 2's developers opted for a more comedic tone to set the game apart from the Grand Theft Auto series, with which the original game was compared by most reviewers for their similar premise and gameplay elements. The game's promotional effort included various public showings, special editions and downloadable content including the Ultor Exposed and Corporate Warfare mission packages. Reviews were largely favorable, praising the action and straightforward gameplay, while only criticizing technical issues. The Windows port in particular was heavily criticized for technical issues not present in any of the other versions. The game had sold around 400,000 units by November 2008, and 3.4 million units by September 2010. A sequel, Saints Row: The Third, was released in November 2011.