T-cell antigen - translation to Αγγλικά
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T-cell antigen - translation to Αγγλικά

MOLECULE FOUND ON THE SURFACE OF SOME IMMUNE CELLS
Alpha-beta T-cell antigen receptor; Genes, t-cell receptor; T-cell receptors; Receptors, antigen, t-cell; T-cell antigen receptors; TCRδ1; TCRd1; T cell receptor
  • Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells.

T-cell antigen      

общая лексика

T-клеточный антиген (антиген T-клеточной линии дифференцировки)

T-cell receptor         

медицина

рецептор Т-клетки

cytotoxic T cell         
CELL
Killer T-cell; Killer T cell; Cytotoxic T lymphocyte; Killer T cells; T8 cells; Cytotoxic T lymphocytes; T cytotoxic cell; T-cytotoxic cell; T-cytotoxic cells; Cytotoxic T cells; Cytotoxic T-lymphocyte; Cytotoxic T-cell; Cytotoxic T-lymphocytes; Cytotoxic T-cells; CD8 T-cell; CD8 T-cells; CD8 T cell; CD8 T cells; Cytotoxic CD8 T cell; Cytotoxic CD8 T cells; Cytotoxic CD8 T lymphocytes; Cytotoxic CD8 T lymphocyte; CD8 cytotoxic T cells; CD8 cytotoxic T cell; CD8 cytotoxic T lymphocyte; CD8 cytotoxic T lymphocytes; Cytotoxic t lymphocyte; Cytotoxic t cells; T-lymphocytes, cytotoxic; Cd8-positive t-lymphocytes; CD8+ cytotoxic T cell; CD8 cytotoxic lymphocyte; CD8+ T cells; Cytotoxic t cell; Cytoxic T lymphocytes; Tc cell; Cytoxic T-Cells; Cytotoxic T Cell; Cytotoxic T Cells; T-Killer Cell; Cytolytic T Cell; CD8+ T-cell; CD8+ T-cells; T-Killer Cells; Cytolytic T Cells; Killer T-Cells; Cytoxic T-cell; CD8+ cell; Cytolytic T cells; CD8+; Killer T Cells; CD8+ T cell; CD8 T lymphocyte; CD8+ T lymphocyte; Cytotoxic T-lymphocyte–associated antigen 4; Cytotoxic T-lymphocyte-associated antigen 4; Cytotoxic t-lymphocytes; CD8+ cytotoxic T lymphocyte

общая лексика

цитотоксическая T-клетка

Ορισμός

т
Т, согласная буква те, твердо, 19-я в азбуке (в церк. 20-я); в церковном счислении: Т триста, триста тысяч, в круге, и в точках, см. А
. ·сокр. т. е., то есть; т. к., так как; и т. д. и так далее; и т. п., и тому подобное; т., том; тысяч.

Βικιπαίδεια

T-cell receptor

The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is of relatively low affinity and is degenerate: that is, many TCRs recognize the same antigen peptide and many antigen peptides are recognized by the same TCR.

The TCR is composed of two different protein chains (that is, it is a heterodimer). In humans, in 95% of T cells the TCR consists of an alpha (α) chain and a beta (β) chain (encoded by TRA and TRB, respectively), whereas in 5% of T cells the TCR consists of gamma and delta (γ/δ) chains (encoded by TRG and TRD, respectively). This ratio changes during ontogeny and in diseased states (such as leukemia). It also differs between species. Orthologues of the 4 loci have been mapped in various species. Each locus can produce a variety of polypeptides with constant and variable regions.

When the TCR engages with antigenic peptide and MHC (peptide/MHC), the T lymphocyte is activated through signal transduction, that is, a series of biochemical events mediated by associated enzymes, co-receptors, specialized adaptor molecules, and activated or released transcription factors. Based on the initial receptor triggering mechanism, the TCR belongs to the family of non-catalytic tyrosine-phosphorylated receptors (NTRs).

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