Wharfedale ( WHORF-dayl) is the valley of the upper parts of the River Wharfe and one of the Yorkshire Dales. It is situated within the districts of Craven and Harrogate in North Yorkshire, and the cities of Leeds and Bradford in West Yorkshire. It is the upper valley of the River Wharfe. Towns and villages in Wharfedale (downstream, from west to east) include Buckden, Kettlewell, Conistone, Grassington, Hebden, Bolton Abbey, Addingham, Ilkley, Burley-in-Wharfedale, Otley, Pool-in-Wharfedale, Arthington, Collingham and Wetherby. Beyond Wetherby, the valley opens out and becomes part of the Vale of York.

The section from the river's source to around Addingham is known as Upper Wharfedale and lies in North Yorkshire and in the Yorkshire Dales National Park. The first 15 miles (24 km) or so is known as Langstrothdale, including the settlements of Beckermonds, Yockenthwaite and Hubberholme, famous for its church, the resting place of the writer J. B. Priestley. As it turns southwards, the Wharfe then runs through a green and lush valley, with limestone outcrops, such as Kilnsey Crag, and woodland, generally quite unusual in the Dales.

Below Addingham, the dale broadens and turns to the east. This section is shared between North Yorkshire and West Yorkshire and includes the towns of Ilkley, Otley and Wetherby. The northern side of Lower Wharfedale, opposite Ilkley, Burley-in-Wharfedale and Otley, is in the Nidderdale Area of Outstanding Natural Beauty.

The Yorkshire Dales Rivers Trust has a remit to conserve the ecological condition of Wharfedale, Wensleydale, Swaledale and Nidderdale catchments from their headwaters to the Humber Estuary.