Omega (; capital: Ω, lowercase: ω; Ancient Greek ὦ, later ὦ μέγα, Modern Greek ωμέγα) is the twenty-fourth and final letter in the Greek alphabet. In the Greek numeric system/isopsephy (gematria), it has a value of 800. The word literally means "great O" (ō mega, mega meaning "great"), as opposed to omicron, which means "little O" (o mikron, micron meaning "little").

In phonetic terms, the Ancient Greek Ω represented a long open-mid back rounded vowel IPA: [ɔː], comparable to the "aw" of the English word raw in dialects without the cot–caught merger, in contrast to omicron which represented the close-mid back rounded vowel IPA: [o] , and the digraph ου which represented the long close-mid back rounded vowel IPA: [oː]. In Modern Greek, both omega and omicron represent the mid back rounded vowel IPA: [o̞] or IPA: [ɔ̝]. The letter omega is transliterated into a Latin-script alphabet as ō or simply o.

As the final letter in the Greek alphabet, omega is often used to denote the last, the end, or the ultimate limit of a set, in contrast to alpha, the first letter of the Greek alphabet; see Alpha and Omega.