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What (who) is 3α-Hydroxysteroid dehydrogenase - definition
3α-Hydroxysteroid dehydrogenase
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
3α-hydroxysteroid dehydrogenase; AKR1C4; AKR1C4 (gene); 3-alpha-HSD; 3α-Hydroxysteroid dehydrogenases; HSD3a; 3α-hydroxysteroid oxidoreductase; 3α-Hydroxysteroid oxidoreductase
3α-Hydroxysteroid dehydrogenase (3α-HSD or aldo-keto reductase family 1 member C4) is an enzyme that in humans is encoded by the AKR1C4 gene. It is known to be necessary for the synthesis of the endogenous neurosteroids allopregnanolone, THDOC, and 3α-androstanediol.
Hydroxysteroid dehydrogenase
![[[Steroidogenesis]].](https://commons.wikimedia.org/wiki/Special:FilePath/Steroidogenesis.svg?width=200 "[[Steroidogenesis]].")
CLASS OF OXIDOREDUCTASE ENZYMES HAT CATALYZE THE DEHYDROGENATION OF HYDROXYSTEROIDS
3-alpha hydroxysteroid dehydrogenase; Hydroxysteroid dehydrogenases; Hydrosteroid dehydrogenase; Ketosteroid reductase; Ketosteroid reductases
Hydroxysteroid dehydrogenases (HSDs) are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids. These enzymes also catalyze the reverse reaction, acting as ketosteroid reductases (KSRs).
17β-Hydroxysteroid dehydrogenase
CLASS OF ENZYMES
17-beta-hydroxysteroid dehydrogenase isozyme 3; 17BHSD3; 3(or 17)b-hydroxysteroid dehydrogenase; 17β-hydroxysteroid dehydrogenase; 17b-hydroxysteroid dehydrogenase; 17b-Hydroxysteroid dehydrogenase; 17bHydroxysteroid-Dehydrogenase; 17B-HSD; EC 1.1.1.51; 3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase; 17Beta Hydroxysteroid dehydrogenase; 17β hydroxysteroid dehydrogenase; 17-ketosteroid reductase; 17-Ketosteroid reductase; 17-Ketosteroid reductases; 17-ketosteroid reductases; 17-ketosteroid oxidoreductases; 17-ketosteroid oxidoreductase; 17-Ketosteroid oxidoreductase; 17-Ketosteroid oxidoreductases; 17-Ketoreductases; 17-Ketoreductase; 17-ketoreductase; 17-ketoreductases; HSD17B; 17β-HSD; 17β-Hydroxysteroid dehydrogenases; 17β-hydroxysteroid dehydrogenases; 17β-HSDs; HSD17Bs; HSD17B*; 17-KSR; 17-KSRs; 17β-Hydroxysteroid dehydrogenase inhibitor; 17β-Hydroxysteroid dehydrogenase inhibitors; 17β-hydroxysteroid dehydrogenase inhibitors; 17β-hydroxysteroid dehydrogenase inhibitor; 17β-HSD inhibitor; 17β-HSD inhibitors; 17beta-HSD inhibitor; 17beta-HSD inhibitors; 17beta-hydroxysteroid dehydrogenase inhibitors; 17beta-hydroxysteroid dehydrogenase inhibitor; 17beta-Hydroxysteroid dehydrogenase inhibitor; 17beta-Hydroxysteroid dehydrogenase inhibitors; 17B-Hydroxysteroid dehydrogenase inhibitors; 17B-Hydroxysteroid dehydrogenase inhibitor; 17B-hydroxysteroid dehydrogenase inhibitor; 17B-hydroxysteroid dehydrogenase inhibitors; 17B-HSD inhibitor; 17B-HSD inhibitors; 17-beta-HSD inhibitors; 17-beta-HSD inhibitor; 17-beta-hydroxysteroid dehydrogenase inhibitor; 17-beta-hydroxysteroid dehydrogenase inhibitors; 17-beta-Hydroxysteroid dehydrogenase inhibitors; 17-beta-Hydroxysteroid dehydrogenase inhibitor
17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B) (), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism. This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol.
