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What (who) is B(0, )-type amino acid transporter 1 - definition
FAMILY OF PROTEIN COMPLEXES
Large neutral amino acid-transporter 1; Antigens, cd98; Large neutral amino acid transporter; LAT1; Cd98 antigens; Large neutral amino acid transporter 1
Heterodimeric amino-acid transporter
Heterodimeric amino acid transporters; Heterodimeric amino acid transporter
Heterodimeric amino-acid transporters are a family of transport proteins that facilitate the transport of certain amino acids across cell membranes. Each comprises a light and a heavy protein subunit.
Amino acid transporter
MEMBRANE TRANSPORT PROTEIN
Sodium-amino acid symporter; Neutral amino acid transporter
An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.
Essential amino acid
AMINO ACID THAT CANNOT BE SYNTHESIZED DE NOVO BY THE ORGANISM
Essential aminoacid; Essential aminoacids; Essential amino acids; Complementary protein; Non-essential amino acid; Amino acid profile; Essential aa; Amino acids, essential; Limiting amino acid; Essential protein; Semi Essential amino acid; Conditionally essential amino acid
An essential amino acid, or indispensable amino acid, is an amino acid that cannot be synthesized from scratch by the organism fast enough to supply its demand, and must therefore come from the diet. Of the 21 amino acids common to all life forms, the nine amino acids humans cannot synthesize are phenylalanine, valine, threonine, tryptophan, methionine, leucine, isoleucine, lysine, and histidine.
Wikipedia
CD98
CD98 is a glycoprotein that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids. LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:
- 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene
- CD98 light subunit protein encoded by the SLC7A5 gene
