Combinatorial biology - meaning and definition. What is Combinatorial biology
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What (who) is Combinatorial biology - definition


Combinatorial biology         
CREATION OF A LARGE NUMBER OF COMPOUNDS (E.G. PROTEINS, PEPTIDES) THROUGH TECHNOLOGIES SUCH AS PHAGE DISPLAY
In biotechnology, combinatorial biology is the creation of a large number of compounds (usually proteins or peptides) through technologies such as phage display. Similar to combinatorial chemistry, compounds are produced by biosynthesis rather than organic chemistry.
Combinatorial chemistry         
  •  Peptides forming in cycles 3 and 4
  • Example of a solid-phase supported dye to signal ligand binding
  • A 27-member tripeptide full library and the three omission libraries. The color circles are amino acids
  • Positional scanning. Full trimer peptide library made from 3 amino acids and its 9 sublibraries. The first row shows the coupling positions
  • Compounds that can be synthesized from solid-phase bound imines
  • Recursive deconvolution. Blue, yellow and red circles: amino acids, Green circle: solid support
  • Flow diagram of the split-mix combinatorial synthesis
  • Use of a solid-supported polyamine to scavenge excess reagent
  • Use of a traceless linker
CHEMICAL METHODS DESIGNED TO RAPIDLY SYNTHESIZE LARGE NUMBERS OF CHEMICAL COMPOUNDS
Combinatorial Chemistry; Combichem; Combinational chemistry; Combinatorial libraries; Combinatorial library; Combinatorial synthesis; High-throughput chemistry; Combinatorial chemistry techniques
Combinatorial chemistry comprises chemical synthetic methods that make it possible to prepare a large number (tens to thousands or even millions) of compounds in a single process. These compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software.
Combinatorial principles         
  • Inclusion–exclusion illustrated for three sets
COMBINATORIAL METHODS USED IN COMBINATORICS, A BRANCH OF MATHEMATICS
Combinatorial principle; Combinatorial methods; Counting principle; Counting principles
In proving results in combinatorics several useful combinatorial rules or combinatorial principles are commonly recognized and used.