The F region of the ionosphere is home to the F layer of ionization, also called the Appleton–Barnett layer, after the English physicist Edward Appleton and New Zealand physicist and meteorologist Miles Barnett. As with other ionospheric sectors, 'layer' implies a concentration of plasma, while 'region' is the volume that contains the said layer. The F region contains ionized gases at a height of around 150–800 km (100 to 500 miles) above sea level, placing it in the Earth's thermosphere, a hot region in the upper atmosphere, and also in the heterosphere, where chemical composition varies with height. Generally speaking, the F region has the highest concentration of free electrons and ions anywhere in the atmosphere. It may be thought of as comprising two layers, the F1 and F2 layers.

The F-region is located directly above the E region (formerly the Kennelly-Heaviside layer) and below the protonosphere. It acts as a dependable reflector of HF radio signals as it is not affected by atmospheric conditions, although its ionic composition varies with the sunspot cycle. It reflects normal-incident frequencies at or below the critical frequency (approximately 10 MHz) and partially absorbs waves of higher frequency.