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What (who) is GEN1, Holliday junction 5' flap endonuclease - definition
GEN1, Holliday junction 5' flap endonuclease
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
Gen1, holliday junction 5' flap endonuclease
GEN1, Holliday junction 5' flap endonuclease is a protein that in humans is encoded by the GEN1 gene.
Crossover junction endodeoxyribonuclease
CLASS OF ENZYMES
EC 3.1.22.4; Hje endonuclease; Holliday junction endonuclease CCE1; Holliday junction resolvase; Holliday junction-cleaving endonuclease; Holliday junction-resolving endoribonuclease; RusA Holliday junction resolvase; RusA endonuclease; RuvC endonuclease; SpCCe1 Holliday junction resolvase; Crossover junction endoribonuclease; Cruciform-cutting endonuclease; Endo X3; Endonuclease RuvC; Endonuclease VII, endonuclease X3; Endonuclease VII; Endonuclease X3; Resolving enzyme CCE1
Crossover junction endodeoxyribonuclease, also known as Holliday junction resolvase, Holliday junction endonuclease, Holliday junction-cleaving endonuclease, Holliday junction-resolving endoribonuclease, crossover junction endoribonuclease, and cruciform-cutting endonuclease, is an enzyme involved in DNA repair and homologous recombination. Specifically, it performs endonucleolytic cleavage that results in single-stranded crossover between two homologous DNA molecules at the Holliday junction to produce recombinant DNA products for chromosomal segregation.
Holliday junction
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![The two pathways for [[homologous recombination]] in [[eukaryote]]s, showing the formation and resolution of Holliday junctions](https://commons.wikimedia.org/wiki/Special:FilePath/HR schematic diagram.svg?width=200 "The two pathways for [[homologous recombination]] in [[eukaryote]]s, showing the formation and resolution of Holliday junctions")
![Schematic diagrams of the three base-stacking [[conformational isomer]]s of the Holliday junction. The two stacked conformers differ in which sets of two arms are bound by [[coaxial stacking]]: at left, the stacks are red–blue and cyan–magenta, while at right the stacks are red–cyan and blue–magenta. The bases nearest to the junction point determine which stacked isomer dominates.](https://commons.wikimedia.org/wiki/Special:FilePath/Holliday junction stacking isomers.svg?width=200 "Schematic diagrams of the three base-stacking [[conformational isomer]]s of the Holliday junction. The two stacked conformers differ in which sets of two arms are bound by [[coaxial stacking]]: at left, the stacks are red–blue and cyan–magenta, while at right the stacks are red–cyan and blue–magenta. The bases nearest to the junction point determine which stacked isomer dominates.")
BRANCHED NUCLEIC ACID STRUCTURE CONTAINING FOUR DOUBLE-STRANDED ARMS
Holliday Junction; Holliday junction resolvases; Dna, cruciform; Holliday intermediate; Holliday junctions; User:Cantusn/sandbox
A Holliday junction is a branched nucleic acid structure that contains four double-stranded arms joined. These arms may adopt one of several conformations depending on buffer salt concentrations and the sequence of nucleobases closest to the junction.
