extremal hypoxia - meaning and definition. What is extremal hypoxia
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What (who) is extremal hypoxia - definition

FAMILY OF PROTEIN COMPLEXES
Hypoxia inducible factor; Hypoxia Inducible Factors; Hypoxia-inducible factor 1; Hypoxia inducible factor 1a; Hypoxia Inducible Factor; HIF-1; Hypoxia-inducible factors; Hypoxia inducible factors; Hypoxia signaling; Hypoxia-inducible factor-1; Hif1
  • Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability. Under normoxic conditions, Hif-1 alpha is hydroxylated at two proline residues. It then associates with VHL and is tagged with ubiquitin resulting in proteasomal degradation. Under hypoxic conditions, Hif-1 alpha translocates to the cell nucleus and associates with Hif-1 beta. This complex then binds to the HRE region of the DNA resulting in the transcription of genes that are involved in a multitude of processes including erythropoesis, glycolysis, and angiogenesis.

Silent hypoxia         
FORM OF HYPOXIA THAT DOES NOT COINCIDE WITH SHORTNESS OF BREATH
Draft:Silent hypoxia; Happy hypoxia
Silent hypoxia (also happy hypoxia) is hypoxia that does not coincide with shortness of breath. It is known to be a complication of COVID-19.
Hypoxia-inducible factor         
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia.
Intrauterine hypoxia         
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HUMAN DISEASE
Fetal hypoxia
Intrauterine hypoxia (also known as fetal hypoxia) occurs when the fetus is deprived of an adequate supply of oxygen. It may be due to a variety of reasons such as prolapse or occlusion of the umbilical cord, placental infarction, maternal diabetes (prepregnancy or gestational diabetes) and maternal smoking.

Wikipedia

Hypoxia-inducible factor

Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. They are only present in parahoxozoan animals.