A dzo (also spelled zo, zho and dzho, Standard Tibetan: མཛོ་, romanized: mdzo) is a hybrid between the yak and domestic cattle. The word dzo technically refers to a male hybrid, while a female is known as a dzomo or zhom. In Mongolian, it is called a khainag (хайнаг). There is also the English language portmanteau term of yattle, a combination of the words yak and cattle, as well as yakow, a combination of the words yak and cow.

Dzomo are fertile (or, fecund) while dzo are sterile. As they are a product of the hybrid genetic phenomenon of heterosis (hybrid vigor), they are larger and stronger than yak or cattle from the region. In Mongolia and Tibet, khainags are thought to be more productive than cattle or yaks in terms of both milk and meat production.

Dzomo can be back crossed. As a result, many supposedly pure yak or pure cattle probably carry each other's genetic material. In Mongolia, the result of a khainag crossed with either a domestic bull or yak bull is called ortoom (ортоом, three-quarter-bred) and an ortoom crossed with a domestic bull or yak bull results in a usan güzee (усан гүзээ, one-eighth-bred).

Dzo inherit two different types of proteins, one from each parent, and their mitochondrial structure and function changes. This significantly changes the dzo's ability to survive in higher altitudes than both parents can.