Quito (Spanish pronunciation: [ˈkito] (listen); Quechua: Kitu), formally San Francisco de Quito, is the capital of Ecuador, with an estimated population of 2.8 million in its urban area. It is also the capital of the province of Pichincha. Quito is located in a valley on the eastern slopes of Pichincha, an active stratovolcano in the Andes, at an elevation of 2,850 m (9,350 ft), making it the second-highest capital city in the world.

Quito is the political and cultural center of Ecuador as the country's major governmental, administrative, and cultural institutions are located within the city. The majority of transnational companies with a presence in Ecuador are headquartered there. It is also one of the country's two major industrial centers—the port city of Guayaquil being the other one.

The date of its first habitation is unknown, but archaeological evidence suggests that it was first settled by sedentary populations between 4400 and 1600 BC. In the late fifteenth century, the Inca Emperor Huayna Capac defeated the Quitu, the region's original inhabitants, and incorporated Quito into the Inca Empire, designating it into the capital of the Inca Empire's northern region. The Spanish conquest of the city in 1534 is the date most frequently cited as the city's official founding, making Quito the oldest capital in South America.

Quito's historic center is among the largest and best-preserved in the Americas. In 1978, Quito and Kraków were the first World Cultural Heritage Sites declared by UNESCO. Quito is the capital city closest to the Equator, with its northern limits ending about 1 km (0.62 miles) south of the line.

In 2008, the city was designated as the headquarters of the Union of South American Nations.