hypoxia$37118$ - translation to german
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hypoxia$37118$ - translation to german

FAMILY OF PROTEIN COMPLEXES
Hypoxia inducible factor; Hypoxia Inducible Factors; Hypoxia-inducible factor 1; Hypoxia inducible factor 1a; Hypoxia Inducible Factor; HIF-1; Hypoxia-inducible factors; Hypoxia inducible factors; Hypoxia signaling; Hypoxia-inducible factor-1; Hif1
  • Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability. Under normoxic conditions, Hif-1 alpha is hydroxylated at two proline residues. It then associates with VHL and is tagged with ubiquitin resulting in proteasomal degradation. Under hypoxic conditions, Hif-1 alpha translocates to the cell nucleus and associates with Hif-1 beta. This complex then binds to the HRE region of the DNA resulting in the transcription of genes that are involved in a multitude of processes including erythropoesis, glycolysis, and angiogenesis.

hypoxia      
n. Hypoxie, Sauerstoffmangel in Gewebe (med.)

Definition

hypoxia
[h??'p?ks??]
¦ noun Medicine deficiency in the amount of oxygen reaching the tissues.
?Ecology oxygen deficiency in a biotic environment.
Derivatives
hypoxic adjective
Origin
1940s: from hypo- + oxygen + -ia1.

Wikipedia

Hypoxia-inducible factor

Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. They are only present in parahoxozoan animals.