Spacecraft propulsion is any method used to accelerate spacecraft and artificial satellites. In-space propulsion exclusively deals with propulsion systems used in the vacuum of space and should not be confused with space launch or atmospheric entry.

Several methods of pragmatic spacecraft propulsion have been developed each having its own drawbacks and advantages. Most satellites have simple reliable chemical thrusters (often monopropellant rockets) or resistojet rockets for orbital station-keeping and some use momentum wheels for attitude control. Soviet bloc satellites have used electric propulsion for decades, and newer Western geo-orbiting spacecraft are starting to use them for north–south station-keeping and orbit raising. Interplanetary vehicles mostly use chemical rockets as well, although a few have used ion thrusters and Hall-effect thrusters (two different types of electric propulsion) to great success.

Hypothetical in-space propulsion technologies describe the propulsion technologies that could meet future space science and exploration needs. These propulsion technologies are intended to provide effective exploration of the Solar System and will permit mission designers to plan missions to "fly anytime, anywhere, and complete a host of science objectives at the destinations" and with greater reliability and safety. With a wide range of possible missions and candidate propulsion technologies, the question of which technologies are "best" for future missions is a difficult one. A portfolio of propulsion technologies should be developed to provide optimum solutions for a diverse set of missions and destinations.