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Partington is a town and civil parish in the Metropolitan Borough of Trafford, Greater Manchester, England, ten miles (16 km) south-west of Manchester city centre. Within the boundaries of the historic county of Cheshire, it lies on the southern bank of the Manchester Ship Canal, opposite Cadishead on the northern bank. It has a population of 7,327.
The completion of the Manchester Ship Canal in 1894 transformed Partington into a major coal-exporting port and attracted other industries. Until 2007 Shell Chemicals UK operated a major petrochemicals manufacturing complex in Carrington, Partington's closest neighbour to the east. The gas storage facility in the north-eastern corner of the town was once a gasworks and another significant employer.
Shortly after the Second World War, local authorities made an effort to rehouse people away from Victorian slums in inner-city Manchester. An area of Partington became an overspill estate and is now one of the most deprived parts of Greater Manchester. The Cheshire Lines Committee opened a railway line through the town in 1873, but it closed in 1964.