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Marinescu-Sjogren syndrome - translation to russian
![T2-weighted MRI]] images of a 25-year-old male with Sjögren–Larsson syndrome revealing dysmyelination in the deep periventricular [[white matter]] and reduced brain volume in the [[frontal lobe]].](https://commons.wikimedia.org/wiki/Special:FilePath/Sjögren-Larsson T2-MRI.jpg?width=200 "T2-weighted MRI]] images of a 25-year-old male with Sjögren–Larsson syndrome revealing dysmyelination in the deep periventricular [[white matter]] and reduced brain volume in the [[frontal lobe]].")
психиатрия
синдром Маринеску-Шегрена
психиатрия
синдром Шегрена-Ларссона
медицина
гипофизарный евнухоидизм
адипозогенитальная дистрофия
гипофизарное ожирение
Definition
Wikipedia
Sjögren–Larsson syndrome is a rare autosomal recessive form of ichthyosis with neurological symptoms.: 485 : 564 It can be identified by a triad of medical disorders. The first is ichthyosis, which is a buildup of skin to form a scale-like covering that causes dry skin and other problems. The second identifier is paraplegia which is characterized by leg spasms. The final identifier is intellectual delay.
SLS is caused by a mutation in the fatty aldehyde dehydrogenase gene found on chromosome 17. In order for a child to receive SLS both parents must be carriers of the SLS gene. If they are carriers their child has a 1⁄4 chance of getting the disease. In 1957 Sjögren and Larsson proposed that the Swedes with the disease all descended from a common ancestor 600 years ago. Today only 30–40 persons in Sweden have this disease.
