Goodpasture's epitope (english) - meaning, definition, translation, pronunciation

Part of Speech

Noun

Phonetic Transcription

/gʊdˈpɑːstʃərz ˈɛpɪˌtoʊp/

Meaning and Usage

Goodpasture's epitope refers specifically to a protein structure that is recognized by antibodies in certain autoimmune diseases, most notably Goodpasture's syndrome. This epitope is typically found in type IV collagen of the glomerular basement membrane in the kidneys and alveoli of the lungs.

The term is more likely to appear in specialized medical literature, particularly in immunology and pathology, rather than in everyday spoken English. Its usage is relatively infrequent compared to more common medical terms and is limited to specific contexts involving autoimmune conditions.

Example sentences: - "Research has shown that Goodpasture's epitope is a primary target in antibody-mediated kidney disease."
(La investigación ha mostrado que el epítopo de Goodpasture es un objetivo principal en la enfermedad renal mediada por anticuerpos.)

• "Detection of Goodpasture's epitope can aid in diagnosing Goodpasture's syndrome."
  (La detección del epítopo de Goodpasture puede ayudar a diagnosticar el síndrome de Goodpasture.)

• "Patients with antibodies against Goodpasture's epitope often experience lung and kidney issues."
  (Los pacientes con anticuerpos contra el epítopo de Goodpasture a menudo experimentan problemas pulmonares y renales.)

Idiomatic Expressions

While "Goodpasture's epitope" may not have direct idiomatic expressions associated with it due to its specific medical context, it does relate closely to concepts in immunology. However, there are relevant idioms in the context of autoimmune diseases and immunological responses:

• "Throwing a tantrum" - When the immune system mistakenly attacks the body's own cells as if they were foreign invaders.

• "In autoimmune diseases like Goodpasture's syndrome, it's as if the body is throwing a tantrum against its own tissues."
  (En enfermedades autoinmunitarias como el síndrome de Goodpasture, es como si el cuerpo estuviera arrojando un berrinche contra sus propios tejidos.)

• "A double-edged sword" - Referring to the immune response that both protects and sometimes harms the body.

• "The immune system is a double-edged sword; while it defends against pathogens, it can also target Goodpasture's epitope."
  (El sistema inmunológico es una espada de doble filo; mientras defiende contra patógenos, también puede atacar el epítopo de Goodpasture.)

Etymology

The term "Goodpasture" is named after the American pathologist Ernest William Goodpasture, who researched the disease associated with this epitope. The term "epitope" originates from the Greek word "epi" meaning "upon" and "topos" meaning "place," collectively referring to the specific part of an antigen recognized by antibodies.

Synonyms and Antonyms

Synonyms: - Antigenic determinant
- Immunogenic site

Antonyms: - Non-epitope (nonspecific regions on proteins) - Non-immunogenic (referring to substances that do not provoke an immune response)