muscle asthenia - traducción al árabe
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muscle asthenia - traducción al árabe

GENETIC DISEASE IN QUARTER HORSES, APPALOOSAS, AND PAINT HORSES
Hyperelastosis cutis; HERDA; Hereditary Equine Regional Dermal Asthenia; Dermal asthenia

muscle asthenia      
‎ وَهَنٌ عَضَلِيّ‎
muscular         
  • When a sarcomere contracts, the Z lines move closer together, and the I band becomes smaller. The A band stays the same width. At full contraction, the thin and thick filaments overlap.
  • (a) Some ATP is stored in a resting muscle. As contraction starts, it is used up in seconds. More ATP is generated from creatine phosphate for about 15 seconds. (b) Each glucose molecule produces two ATP and two molecules of pyruvic acid, which can be used in aerobic respiration or converted to [[lactic acid]]. If oxygen is not available, pyruvic acid is converted to lactic acid, which may contribute to [[muscle fatigue]]. This occurs during strenuous exercise when high amounts of energy are needed but oxygen cannot be sufficiently delivered to muscle. (c) Aerobic respiration is the breakdown of glucose in the presence of oxygen (O2) to produce carbon dioxide, water, and ATP. Approximately 95 percent of the ATP required for resting or moderately active muscles is provided by aerobic respiration, which takes place in mitochondria.
  • ATPase staining of a muscle cross section. Type II fibers are dark, due to the alkaline pH of the preparation. In this example, the size of the type II fibers is considerably less than the type I fibers due to denervation atrophy.
  • Types of [[pennate muscle]]. A – [[unipennate]];  B – [[bipennate]]; 
C – [[multipennate]]
  • [[Human embryo]] showing [[somite]]s labelled as ''primitive segments''.
  • polypeptide]] tail (only one tail of each pair is shown). The pairs of histones, H2A, H2B, H3 and H4, each have [[lysine]]s (K) in their tails, some of which are subject to post-translational modifications consisting, usually, of acetylations [Ac] and methylations {me}. The lysines (K) are designated with a number showing their position as, for instance, (K4), indicating lysine as the 4th amino acid from the amino (N) end of the tail in the histone protein. The particular acetylations [Ac] and methylations {Me} shown are those that occur on nucleosomes close to, or at, some DNA regions undergoing transcriptional activation of the DNA wrapped around the nucleosome.
  • Prisoner of war exhibiting muscle loss as a result of [[malnutrition]].
  • [[Jogging]] is one form of aerobic exercise.
  • Muscle types by fiber arrangement
  • Exercise-induced signaling pathways in skeletal muscle that determine specialized characteristics of slow- and fast-twitch muscle fibers
  • In [[muscular dystrophy]], the affected tissues become disorganized and the concentration of [[dystrophin]] (green) is greatly reduced.
  •  
'''Regulation of transcription in mammals.'''  An active enhancer regulatory region is enabled to interact with the promoter region of its target gene by formation of a chromosome loop. This can allow initiation of messenger RNA (mRNA) synthesis by RNA polymerase II (RNAP II) bound to the promoter at the transcription start site of the gene. The loop is stabilized by one architectural protein anchored to the enhancer and one anchored to the promoter, and these proteins are joined together to form a dimer (red zigzags). Specific regulatory transcription factors bind to DNA sequence motifs on the enhancer. General transcription factors bind to the promoter. When a transcription factor is activated by a signal (here indicated as phosphorylation shown by a small red star on a transcription factor on the enhancer) the enhancer is activated and can now activate its target promoter. The active enhancer is transcribed on each strand of DNA in opposite directions by bound RNAP IIs. Mediator (a complex consisting of about 26 proteins in an interacting structure) communicates regulatory signals from the enhancer DNA-bound transcription factors to the promoter.
  • Structure of muscle fibre showing a sarcomere under [[electron microscope]] with schematic explanation.
ONE OF THREE MAJOR MUSCLE TYPES
Skeletal muscles; Voluntary muscle; Musculo; Red skeletal muscle cell; White skeletal muscle cell; Muscle protein; Fast twitch muscle; Slow twitch muscles; Skeletal Muscle; Strongest muscle in human body; Muscle loss; Musculature; Muscle mass; Muscle, skeletal; Muscular branches; Muscle fibers, slow-twitch; Muscular diseases; Myoblasts, skeletal; Control of Muscles; Voluntary muscles; Characteristics of muscle; Muscular fiber; Skeletal muscular; Lean muscle; Muscles; Slow-twitch muscle; Panniculus carnosis; Neoplasms, muscle tissue; Excitation-contraction; Muscle proteins; Muscle strength; Muscle; Myoid cells; Branchialis; Connective tissue in skeletal muscle; Connective tissue of skeletal muscle; Muscle types; Convergent muscles; Human muscle; Fast-twitching; Textus muscularis striatus skeletalis; Skeletal muscle cells; Muscular; Gross anatomy of muscles; Muscular force; Myo-; Skeletal striated muscles; Fast twitch fibre; Slow twitch fibre; Slow twitch fiber; Fast twitch fiber; Skeletal striated muscle; Muscular fibers; Myonuclei; Evolution of muscles; Skeletal muscle fibers; Myotendinous junction; Muscle group; Groups of muscles; Msucle; Musculotendinous junction; Skeletal muscle cell
صِفَة : عَضَلِيّ . قويّ
MUSCULAR         
  • When a sarcomere contracts, the Z lines move closer together, and the I band becomes smaller. The A band stays the same width. At full contraction, the thin and thick filaments overlap.
  • (a) Some ATP is stored in a resting muscle. As contraction starts, it is used up in seconds. More ATP is generated from creatine phosphate for about 15 seconds. (b) Each glucose molecule produces two ATP and two molecules of pyruvic acid, which can be used in aerobic respiration or converted to [[lactic acid]]. If oxygen is not available, pyruvic acid is converted to lactic acid, which may contribute to [[muscle fatigue]]. This occurs during strenuous exercise when high amounts of energy are needed but oxygen cannot be sufficiently delivered to muscle. (c) Aerobic respiration is the breakdown of glucose in the presence of oxygen (O2) to produce carbon dioxide, water, and ATP. Approximately 95 percent of the ATP required for resting or moderately active muscles is provided by aerobic respiration, which takes place in mitochondria.
  • ATPase staining of a muscle cross section. Type II fibers are dark, due to the alkaline pH of the preparation. In this example, the size of the type II fibers is considerably less than the type I fibers due to denervation atrophy.
  • Types of [[pennate muscle]]. A – [[unipennate]];  B – [[bipennate]]; 
C – [[multipennate]]
  • [[Human embryo]] showing [[somite]]s labelled as ''primitive segments''.
  • polypeptide]] tail (only one tail of each pair is shown). The pairs of histones, H2A, H2B, H3 and H4, each have [[lysine]]s (K) in their tails, some of which are subject to post-translational modifications consisting, usually, of acetylations [Ac] and methylations {me}. The lysines (K) are designated with a number showing their position as, for instance, (K4), indicating lysine as the 4th amino acid from the amino (N) end of the tail in the histone protein. The particular acetylations [Ac] and methylations {Me} shown are those that occur on nucleosomes close to, or at, some DNA regions undergoing transcriptional activation of the DNA wrapped around the nucleosome.
  • Prisoner of war exhibiting muscle loss as a result of [[malnutrition]].
  • [[Jogging]] is one form of aerobic exercise.
  • Muscle types by fiber arrangement
  • Exercise-induced signaling pathways in skeletal muscle that determine specialized characteristics of slow- and fast-twitch muscle fibers
  • In [[muscular dystrophy]], the affected tissues become disorganized and the concentration of [[dystrophin]] (green) is greatly reduced.
  •  
'''Regulation of transcription in mammals.'''  An active enhancer regulatory region is enabled to interact with the promoter region of its target gene by formation of a chromosome loop. This can allow initiation of messenger RNA (mRNA) synthesis by RNA polymerase II (RNAP II) bound to the promoter at the transcription start site of the gene. The loop is stabilized by one architectural protein anchored to the enhancer and one anchored to the promoter, and these proteins are joined together to form a dimer (red zigzags). Specific regulatory transcription factors bind to DNA sequence motifs on the enhancer. General transcription factors bind to the promoter. When a transcription factor is activated by a signal (here indicated as phosphorylation shown by a small red star on a transcription factor on the enhancer) the enhancer is activated and can now activate its target promoter. The active enhancer is transcribed on each strand of DNA in opposite directions by bound RNAP IIs. Mediator (a complex consisting of about 26 proteins in an interacting structure) communicates regulatory signals from the enhancer DNA-bound transcription factors to the promoter.
  • Structure of muscle fibre showing a sarcomere under [[electron microscope]] with schematic explanation.
ONE OF THREE MAJOR MUSCLE TYPES
Skeletal muscles; Voluntary muscle; Musculo; Red skeletal muscle cell; White skeletal muscle cell; Muscle protein; Fast twitch muscle; Slow twitch muscles; Skeletal Muscle; Strongest muscle in human body; Muscle loss; Musculature; Muscle mass; Muscle, skeletal; Muscular branches; Muscle fibers, slow-twitch; Muscular diseases; Myoblasts, skeletal; Control of Muscles; Voluntary muscles; Characteristics of muscle; Muscular fiber; Skeletal muscular; Lean muscle; Muscles; Slow-twitch muscle; Panniculus carnosis; Neoplasms, muscle tissue; Excitation-contraction; Muscle proteins; Muscle strength; Muscle; Myoid cells; Branchialis; Connective tissue in skeletal muscle; Connective tissue of skeletal muscle; Muscle types; Convergent muscles; Human muscle; Fast-twitching; Textus muscularis striatus skeletalis; Skeletal muscle cells; Muscular; Gross anatomy of muscles; Muscular force; Myo-; Skeletal striated muscles; Fast twitch fibre; Slow twitch fibre; Slow twitch fiber; Fast twitch fiber; Skeletal striated muscle; Muscular fibers; Myonuclei; Evolution of muscles; Skeletal muscle fibers; Myotendinous junction; Muscle group; Groups of muscles; Msucle; Musculotendinous junction; Skeletal muscle cell

الصفة

عَضِل ; مَفْتُولُ السَّاعِدِ أو العَضَل

Definición

smooth muscle
¦ noun Physiology muscle tissue in which the contractile fibrils are not highly ordered, occurring in the gut and other internal organs and not under voluntary control. Often contrasted with striated muscle.

Wikipedia

Hereditary equine regional dermal asthenia

Hereditary equine regional dermal asthenia (HERDA), also known as hyperelastosis cutis (HC), is an inherited autosomal recessive connective tissue disorder. It develops from a homozygous recessive mutation that weakens collagen fibers that allow the skin of the animal to stay connected to the rest of the animal. Affected horses have extremely fragile skin that tears easily and exhibits impaired healing. In horses with HC, the skin separates between the deep and superficial dermis. There is no cure. Most affected individuals receive an injury they cannot heal, and are euthanized. Managed breeding strategy is currently the only option for reducing the incidence of the disease.

The disease is found primarily in the American Quarter Horse, specifically in cutting horse lines. Affected horses have been found to trace to the stallion Poco Bueno, or possibly, farther back to one of his ancestors. Researchers have now named four deceased Quarter Horse stallions that were carriers and produced at least one affected HERDA foal; they are Dry Doc, Doc O'Lena, Great Pine, and Zippo Pine Bar. These stallions all trace to Poco Bueno through his son and daughter Poco Pine and Poco Lena. Other breeds affected are the American Paint Horse, and the Appaloosa and any other breed registry that allows outcrossing to AQHA horses.

HERDA is characterized by abnormal skin along the back that tears or rips easily and heals into disfiguring scars. The skin is loose, and hyper-elastic in affected horses. This collagen based abnormality affects their heart valves too and their mechanical properties are found to be inferior to native horses. Symptoms typically don’t appear until the horse is subjected to pressure or injury on their back, neck or hips, usually around two years of age. However foals can show signs when injured, while other horses mature and only show signs in the joints. The expression of HERDA is variable, and the phenotypic range of expression is still being determined.

After being tested, the results either show "normal", "carrier" or "affected" and can be determined by DNA testing of either a blood or hair sample.

  • N/N — Normal: does not have the HERDA gene
  • N/HRD- Carrier: carries one copy of the gene
  • HRD/HRD- Affected: has two copies of the gene

The expected lifespan of an affected horse is 2–4 years. There is currently no cure for this disease. To prevent it from occurring, the only solution is not to breed horses who both carry the HERDA allele.