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Biological Institute (Instituto Biológico in Portuguese) is an applied research center organised in 1924 in São Paulo, Brazil. It is a governmental organisation concerned with the prevention of zoonoses and foodborne animal pathogens such as rabies and tuberculosis, sanitary advertisement campaigns, alternatives to the chemical control of diseases such as organic farming and biological control.
Among its main achievements are the biological control of the coffee borer beetle in the 1920s in Brazil, the discovery of bradykinin, and the production of vaccines that combat the Newcastle disease, foot-and-mouth disease and the black plague in pigs.