In Boolean functions and propositional calculus, the Sheffer stroke denotes a logical operation that is equivalent to the negation of the conjunction operation, expressed in ordinary language as "not both". It is also called nand ("not and") or the alternative denial, since it says in effect that at least one of its operands is false. In digital electronics, it corresponds to the NAND gate. It is named after Henry M. Sheffer and written as ↑ or as | (but not as ||, often used to represent disjunction). In Bocheński notation it can be written as Dpq.

Its dual is the NOR operator (also known as the Peirce arrow or Quine dagger). Like its dual, NAND can be used by itself, without any other logical operator, to constitute a logical formal system (making NAND functionally complete). This property makes the NAND gate crucial to modern digital electronics, including its use in computer processor design.