Hydroxymethylglutaryl-CoA synthase
CLASS OF ENZYMES
HMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl-coa synthase 1; Acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); Hydroxymethylglutaryl-coa synthase
In molecular biology, hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase is an enzyme which catalyzes the reaction in which acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). This reaction comprises the second step in the mevalonate-dependent isoprenoid biosynthesis pathway.