5-HT2 receptor - significado y definición. Qué es 5-HT2 receptor
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Qué (quién) es 5-HT2 receptor - definición


5-HT2 receptor         
TRANSMEMBRANE PROTEIN
Htr2; 5-HT2
The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). The 5-HT2 subfamily consists of three G protein-coupled receptors (GPCRs) which are coupled to Gq/G11 and mediate excitatory neurotransmission, including 5-HT2A, 5-HT2B, and 5-HT2C.
5-HT2C receptor agonist         
  • '''Figure 1 – Mechanism of action.''' A hypothetical model for the agonist activation of 5-HT<sub>2C</sub> receptor. Activation leads to accumulation of inositol phosphate and increase in intracellular Ca<sup>2+</sup>. Receptor activation also stimulates the ERK pathway and RhoA/PLD pathway.
  • '''Figure 6. [[Lorcaserin]]'''    ((1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine).
  • '''Figure 4.''' The best fit mapped with the four features of the pharmacophore.
  • '''Figure 3.''' Outline of the 5-HT<sub>2C</sub> receptor. The most important contacts when serotonin binds are with residues in TM helixes 3, 5, and 6.
  • '''Figure 2.''' A schematic representation of the two state-model in which the 5-HT<sub>2C</sub> receptor are in equilibrium between an active state (R*) and an inactive state (R).
ENDOGENOUS COMPOUNDS AND DRUGS THAT SPECIFICALLY STIMULATE SEROTONIN 5-HT2 RECEPTORS. INCLUDED UNDER THIS HEADING ARE AGONISTS FOR ONE OR MORE OF THE SPECIFIC 5-HT2 RECEPTOR SUBTYPES
5-HT2C receptor agonists; Wikipedia talk:Articles for creation/5-HT2c receptor agonist; 5-HT2c receptor agonist
5-HT2C receptor agonists are a class of drugs that activate 5-HT2C receptors. They have been investigated for the treatment of a number of conditions including obesity, psychiatric disorders, sexual dysfunction and urinary incontinence.
5-HT1 receptor         
TRANSMEMBRANE PROTEIN
5-HT1; 5-ht1; 5-ht1 receptor; 5HT1B
The 5-HT1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT). The 5-HT1 subfamily consists of five G protein-coupled receptors (GPCRs) that are coupled to Gi/Go and mediate inhibitory neurotransmission, including 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F.