Christopher Cross "Chris" Griffin (born February 8) is a fictional character from the animated television series, Family Guy. He is the second of three children of Peter and Lois Griffin and is also the older brother of Stewie Griffin and the younger brother of Meg Griffin. He is voiced by the American actor, producer and writer, Seth Green, and first appeared on television, along with the rest of the Griffin family, in a 15-minute short on December 20, 1998.

Chris Griffin was created and designed by the American actor and animator, Seth MacFarlane, who was asked to pitch a pilot to the Fox Broadcasting Company. The series pilot episode was based on The Life of Larry and Larry & Steve. It was composed of two shorts made by MacFarlane which featured a middle-aged man named Larry and an intellectual dog, Steve. After the pilot was given the green light, the Griffin family appeared in the episode "Death Has a Shadow".

Originally designed as a somewhat gregarious, yet unintelligent teenager, Chris has become more awkward and idiotic over the course of the show. Running gags in the series involving Chris include the existence of an 'Evil Monkey' in his closet (though it is later revealed that the monkey is not evil), his frequent masturbation, and his perverted admirer, the elderly Herbert who lusts after and repeatedly tries to prey on him throughout the show's run.