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Traducción y análisis de palabras por inteligencia artificial ChatGPT

En esta página puede obtener un análisis detallado de una palabra o frase, producido utilizando la mejor tecnología de inteligencia artificial hasta la fecha:

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etimología

Qué (quién) es prodrug - definición

COMPOUND THAT IS METABOLIZED INTO A PHARMACOLOGICALLY ACTIVE DRUG

Pro-drug; Prodrugs; In vivo conversion; Conversion in vivo; Inactive prodrug

prodrug

¦ noun a biologically inactive compound which can be metabolized in the body to produce a drug.

DEPT (medicine)

CDEPT; ADEPT (medicine); Antibody-directed enzyme prodrug therapy; GDEPT; VDEPT; Directed enzyme prodrug therapy; Directed Enzyme Prodrug Therapy

Directed enzyme prodrug therapy (DEPT) uses enzymes artificially introduced into the body to convert prodrugs, which have no or poor biologically activity, to the active form in the desired location within the body. Many chemotherapy drugs for cancer lack tumour specificity and the doses required to reach therapeutic levels in the tumour are often toxic to other tissues.

https://en.wikipedia.org/wiki/DEPT_(medicine)

Hypoxia-activated prodrug

HYPOXIA-ACTIVATED PRODUGS TARGET TUMOR REGIONS WHICH CELLS ARE MORE RESISTANT TO CONVENTIONAL CHEMOTHERAPY. THIS IS DUE TO A DEEPER POSITIONING FROM CAPILLARIES AND SLOWER CELL DIVISION PRODUCED BY THE LOW-OXYGEN ZONES, UNIDEAL FOR COMMON TREATMENTS.

Hypoxia activated prodrugs; Hypoxia-activated prodrugs

Hypoxia-Activated Prodrugs (HAPs) are prodrugs that target regions of tumor hypoxia within tumor cells. HAPs may offer the potential, alone and in combination with conventional chemotherapy, of improving cancer therapy.

https://en.wikipedia.org/wiki/Hypoxia-activated_prodrug

Wikipedia

Prodrug

A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted (ADME).

Prodrugs are often designed to improve bioavailability when a drug itself is poorly absorbed from the gastrointestinal tract. A prodrug may be used to improve how selectively the drug interacts with cells or processes that are not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects.

https://en.wikipedia.org/wiki/Prodrug