CLR may refer to:

• Calcium Lime Rust, a household cleaning-product
• California Law Review, a publication by the UC Berkeley School of Law
• Centerline Radius, a term in the tubing industry used to describe the radius of a bend
• Central London Railway, an underground railway line in London - now the central part of the London Underground's Central line
• Chief Langalibalele Rifles, an infantry regiment of the South African Army
• Cliff Hatfield Memorial Airport, an airport in Calipatria, California
• CLR (formerly Computer Language Research), a subsidiary of Thomson Reuters Tax & Accounting
• Coffee leaf rust, a plant disease caused by the fungus Hemileia vastatrix
• Combat Logistics Regiment, a type of United States Marine Corps regiment
• Command, Leadership, Resource management, another acronym for Cockpit Resource Management
• Commando Logistic Regiment, a logistic regiment of the Royal Marines
• Commonwealth Law Reports, reports of decisions of the High Court of Australia
• Compagnie Luxembourgeoise de Radiodiffusion, a Luxembourg-based radio-broadcaster - part of RTL Group
• Compensation Log Record, a type of database log record
• Council on Library Resources, USA
• Mercedes-Benz CLR, a racing-car
• The Circle of Liberal Reformers, a political party in Gabon
• A nickname for Introduction to Algorithms by Cormen, Leiserson, and Rivest