protease$64750$ - traduction vers Anglais
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protease$64750$ - traduction vers Anglais

CLASS OF ANTIVIRAL DRUGS USED TO TREAT HIV/AIDS AND HEPATITIS C
Protease inhibitors; Hiv protease inhibitors; HIV protease inhibitor; Pharmacologic protease inhibitor; Protease Inhibitors; HIV protease inhibitors; HCV protease inhibitor
  • The number of people in the U.S. dying of HIV fell by 60% in the 2 years following the introduction of the first HIV protease inhibitors

protease      
n. protease (enzym)

Définition

protease
['pr??t?e?z]
¦ noun Biochemistry an enzyme which breaks down proteins and peptides.
Origin
early 20th cent.: from protein + -ase.

Wikipédia

Protease inhibitor (pharmacology)

Protease inhibitors (PIs) are medications that act by interfering with enzymes that cleave proteins. Some of the most well known are antiviral drugs widely used to treat HIV/AIDS hepatitis C and COVID-19. These protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles.

Protease inhibitors that have been developed and are currently used in clinical practice include:

Given the specificity of the target of these drugs there is the risk, like with antibiotics, of the development of drug-resistant mutated viruses. To reduce this risk, it is common to use several different drugs together that are each aimed at different targets.