Follicle-stimulating hormone insensitivity
MEDICAL CONDITION
Follicle-stimulating hormone resistance; FSH insensitivity; FSH resistance; Ovarian resistance to follicle-stimulating hormone; Ovarian insensitivity to follicle-stimulating hormone; Ovarian resistance to FSH; Ovarian insensitivity to FSH; Ovarian follicle hypoplasia; Ovarian follicle aplasia; Granulosa cell aplasia; Granulosa cell hypoplasia; Ovarian follicle agenesis; Ovarian follicle hypogenesis; Granulosa cell hypogenesis; Granulosa cell agenesis
Follicle-stimulating hormone (FSH) insensitivity, or ovarian insensitivity to FSH in females, also referable to as ovarian follicle hypoplasia or granulosa cell hypoplasia in females, is a rare autosomal recessive genetic and endocrine syndrome affecting both females and males, with the former presenting with much greater severity of symptomatology. It is characterized by a resistance or complete insensitivity to the effects of follicle-stimulating hormone (FSH), a gonadotropin which is normally responsible for the stimulation of estrogen production by the ovaries in females and maintenance of fertility in both sexes.