G protein-coupled receptor kinase 3 - définition. Qu'est-ce que G protein-coupled receptor kinase 3
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Qu'est-ce (qui) est G protein-coupled receptor kinase 3 - définition


G protein-coupled receptor kinase 3         
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
ADRBK2; BARK2; GRK3; ADRBK2 (gene); Beta adrenergic receptor kinase-2; Beta adrenergic receptor kinase 2
G-protein-coupled receptor kinase 3 (GRK3) is an enzyme that in humans is encoded by the ADRBK2 gene. GRK3 was initially called Beta-adrenergic receptor kinase 2 (βARK-2), and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar to GRK2.
G protein-coupled receptor         
  • PDB]] entry [https://web.archive.org/web/20180128134132/https://www.rcsb.org/structure/3SN6 3SN6]). The receptor is colored red, Gα green, Gβ cyan, and Gγ yellow. The C-terminus of Gα is located in a cavity created by an outward movement of the cytoplasmic parts of TM5 and 6.
  • 50px
  •  doi = 10.1210/me.2009-0473 }}</ref>
  • Proposed downstream interactions between [[integrin]] signaling and GPCRs. Integrins are shown elevating Ca<sup>2+</sup> and phosphorylating FAK, which is weakening GPCR signaling.
  •  doi-access = free }}</ref>
  • Cartoon depicting the Heterotrimeric G-protein activation/deactivation cycle in the context of GPCR signaling
  • Two-dimensional schematic of a generic GPCR set in a Lipid Raft. Click the image for higher resolution to see details regarding the locations of important structures.
  • G-protein-coupled receptor mechanism
  • The seven-transmembrane α-helix structure of bovine rhodopsin
  • Activation effects of cAMP on protein kinase A
  • The effect of Ri and Gi in cAMP signal pathway
  • The effect of Rs and Gs in cAMP signal pathway
LARGE PROTEIN FAMILY OF RECEPTORS THAT DETECT MOLECULES OUTSIDE THE CELL AND ACTIVATE INTERNAL SIGNAL TRANSDUCTION PATHWAYS AND CELLULAR RESPONSES
G-protein coupled receptors; G-protein coupled receptor; 7TM receptor; G protein coupled receptor; GPCR; Heptahelical receptor; 7 transmembrane receptor; Seven transmembrane receptor; Seven-transmembrane protein; Seven transmembrane region; G-protein-coupled receptors; Guanine Nucleotide-Binding Protein-Coupled Receptor; 7TM Receptor; 7TM; G-protein-coupled receptor; Receptors, g-protein-coupled; 7-transmembrane G-protein coupled; G-protein coupled; G protein-coupled; 7 transmembrane; 7-transmembrane; G-protein linked receptors; G-protein coupled membrane receptors; G protein-coupled receptors; G-protein-coupled; Serpentine receptor; G protein coupled receptors; Gi coupled receptor; Seven transmembrane protein; 7-transmembrane receptor; Gpcr; Gpcrs; G protein–coupled receptor; GPCRs
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.
GRK6         
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
G protein-coupled receptor kinase 6; GRK6 (gene)
This gene encodes a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family, and is most highly similar to GRK4 and GRK5. The protein phosphorylates the activated forms of G protein-coupled receptors to regulate their signaling.