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Qu'est-ce (qui) est P53 upregulated modulator of apoptosis - définition
P53 upregulated modulator of apoptosis
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
BBC3 (gene)
The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene.
Inhibitor of apoptosis
PROTEINS THAT CONTROL APOPTOSIS
Inhibitor of apoptosis protein; Inhibitors of apoptosis; Inhibitor of apoptosis proteins; CrmA; C-IAP1; Programmed cell death inhibitor; Inhibitors of Apoptosis; Inhibitor of Apoptosis
Inhibitors of apoptosis are a group of proteins that mainly act on the intrinsic pathway that block programmed cell death, which can frequently lead to cancer or other effects for the cell if mutated or improperly regulated. Many of these inhibitors act to block caspases, a family of cysteine proteases that play an integral role in apoptosis.
P53
![p53 immunostain]].](https://commons.wikimedia.org/wiki/Special:FilePath/Anaplastic astrocytoma - p53 - very high mag.jpg?width=200 "p53 immunostain]].")
![Overview of signal transduction pathways involved in [[apoptosis]]](https://commons.wikimedia.org/wiki/Special:FilePath/Signal transduction pathways.svg?width=200 "Overview of signal transduction pathways involved in [[apoptosis]]")
MAMMALIAN PROTEIN FOUND IN HOMO SAPIENS
P53 gene; Protein P53; P53 protein; Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13; Cellular tumor antigen p53; TP53 gene; TP53 (version 2); Tumor suppressor protein p53; The guardian of the genome; Genes, p53; P53 expression; P53 (protein); TP53 (gene); TRP53; Tp53 Gene; P53 tumor suppressor; Tumor protein; P53 signaling pathway; TP53; Guardian of the Genome
Tumor protein P53, also known as p53, cellular tumor antigen p53 (UniProt name), the Guardian of the Genome, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as (humans) and Trp53 (mice). The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation.
