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Qu'est-ce (qui) est T antigen - définition

PROTO-ONCOGENE DERIVED FROM POLYOMAVIRUS SV40

SV40 TAg; T-antigen; SV40 Large T-antigen; T antigen; SV40 large T-antigen; Simian virus 40 large T-antigen; SV40T

SV40 large T antigen

SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types.

https://en.wikipedia.org/wiki/SV40_large_T_antigen

Chimeric antigen receptor T cell

ARTIFICIAL T-CELL RECEPTOR FOR USE IN IMMUNOTHERAPY

Chimeric T cell receptor; Artificial T cell receptors; Artificial t cell receptor; Artificial T cell receptor; Chimeric Antigen Receptor; CAR-T; Genetically engineered T cell; Engineered T-cell; Chimeric antibody receptor; CAR-T therapy; CAR T-cell therapy; CAR-T cell; CAR T cells; Chimeric antigen receptor; CAR-T Cell Therapy; CAR-T cells; Chimeric antigen receptor T cell; CAR T-cell

Chimeric antigen receptor T cells (also known as CAR T cells) are T cells that have been genetically engineered to produce an artificial T cell receptor for use in immunotherapy.

https://en.wikipedia.org/wiki/Chimeric_antigen_receptor_T_cell

T-cell receptor

MOLECULE FOUND ON THE SURFACE OF SOME IMMUNE CELLS

Alpha-beta T-cell antigen receptor; Genes, t-cell receptor; T-cell receptors; Receptors, antigen, t-cell; T-cell antigen receptors; TCRδ1; TCRd1; T cell receptor

The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is of relatively low affinity and is degenerate: that is, many TCRs recognize the same antigen peptide and many antigen peptides are recognized by the same TCR.

https://en.wikipedia.org/wiki/T-cell_receptor

Wikipédia

SV40 large T antigen

SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function. Similar proteins from related viruses are known as large tumor antigen in general.

TAg is a product of an early gene transcribed during viral infection by SV40, and is involved in viral genome replication and regulation of host cell cycle. SV40 is a double-stranded, circular DNA virus belonging to the Polyomaviridae (earlier Papovavirus) family, Orthopolyomavirus genus. Polyomaviruses infect a wide variety of vertebrates and cause solid tumours at multiple sites. SV40 was isolated by Sweet and Maurice Hilleman in 1960 in primary monkey kidney cell cultures being used to grow Sabin OPV.

https://en.wikipedia.org/wiki/SV40 large T antigen