UBE3A - definizione. Che cos'è UBE3A
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Cosa (chi) è UBE3A - definizione


UBE3A         
  • Collision model of UBE3A
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
Ubiquitin protein ligase E3A; E6AP; E6-AP; UBE3A (gene)
Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. This enzyme is involved in targeting proteins for degradation within cells.
Ube3a-ATS         
  • '''The collision model for paternal UBE3A silencing via the UBE3A-ATS'''.
Only one RNA Polymerase (RNAP) can transcribe along a part of the template at a time. When two RNAPs are transcribing in head on directions, a collision can occur. This can result in stalling of both of the RNAPs, backtracking of one RNAP, or falling off of the template. In this case, the RNAP transcribing the paternal UBE3A-ATS competes with the RNAP transcribing UBE3A and pushes it off of the template, preventing UBE3A transcription and allowing UBE3A-ATS transcription. Arrows show the direction of transcription. Reviewed in ''Trends in Neurosci''.<ref name="Mabb2011"/>
  •  doi = 10.1016/j.tins.2011.04.001 }}</ref> The [[AS-IC]] is thought to control methylation of the PWS-IC. The red boxes represent maternally transcribed genes, while the blue represents paternally transcribed genes. The direction of transcription is indicated by the arrows. Adapted from ''Trends in Neurosci''.<ref name="Mabb2011"/>
NON-CODING RNA IN THE SPECIES HOMO SAPIENS
Wikipedia talk:Articles for creation/Ube3a-ATS
UBE3A-ATS/Ube3a-ATS (human/mouse), otherwise known as ubiquitin ligase E3A-ATS, is the name for the antisense DNA strand that is transcribed as part of a larger transcript called LNCAT (large non-coding antisense transcript) at the Ube3a locus. The Ube3a locus is imprinted and in the central nervous system expressed only from the maternal allele.