A conflagration is a large fire. Conflagrations often damage human life, animal life, health, and/or property. A conflagration can begin accidentally or be intentionally created (arson). A very large fire can produce a firestorm, in which the central column of rising heated air induces strong inward winds, which supply oxygen to the fire. Conflagrations can cause casualties including deaths or injuries from burns, trauma due to collapse of structures and attempts to escape, and smoke inhalation.

Firefighting is the practice of extinguishing a conflagration, protecting life and property and minimizing damage and injury. One of the goals of fire prevention is to avoid conflagrations. When a conflagration is extinguished, there is often a fire investigation to determine the cause of the fire.