Who Do You Trust? (originally titled Do You Trust Your Wife? until July 1958) is an American television game show. The show aired from September 30, 1957 to November 15, 1957, at 4:30 pm Eastern on ABC, and from November 18, 1957 to December 27, 1963 at 3:30 pm Eastern. This schedule helped garner a significant number of young viewers coming home from school. (The revised title also outraged English teachers, who preferred "Whom Do You Trust?")

The series was initially emceed by Johnny Carson and announced by Bill Nimmo. A year into the run, Nimmo was replaced by Ed McMahon, and from that point until 1992 Carson and McMahon would spend the majority of their careers together. The pair departed in 1962 when Carson was hired to take over from Jack Paar on NBC's Tonight, which had been retitled The Jack Paar Show (and changed back to an earlier title, The Tonight Show, under Carson), where the two would spend the next thirty years together. Woody Woodbury took over the Who Do You Trust? hosting position while Nimmo returned to announce. The show was produced at the Little Theater on 44th Street in New York (today known as the Helen Hayes Theater).